گیرنده های داروئی ( Drug Receptors )

Pharmacogenetics of Drug Receptors

Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment can develop so called adverse drug reactions (ADRs) as a consequence of the treatment (cause over 100 000 deaths per year in USA). Pharmacogenetics is the discipline, which takes the patient’s genetic information of drug transporters, drug metabolising enzymes and drug receptors into account leadin...

آلرژی های داروئی و غذائی

Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions.

Orally delivered small-molecule therapeutics are metabolized in the liver and intestine by phase I and phase II drug-metabolizing enzymes (DMEs), and transport proteins coordinate drug influx (phase 0) and drug/drug-metabolite efflux (phase III). Genes involved in drug metabolism and disposition are induced by xenobiotic-activated nuclear receptors (NRs), i.e. PXR (pregnane X receptor) and CAR ...

Lysophospholipid receptors in drug discovery.

Lysophospholipids (LPs), including lysophosphatidic acid (LPA), sphingosine 1-phospate (S1P), lysophosphatidylinositol (LPI), and lysophosphatidylserine (LysoPS), are bioactive lipids that transduce signals through their specific cell-surface G protein-coupled receptors, LPA1-6, S1P1-5, LPI1, and LysoPS1-3, respectively. These LPs and their receptors have been implicated in both physiological a...

Drug Receptors and Biological Responses

A fundamental concept of pharmacology is that to initiate an effect in a cell, most drugs combine with some molecular structure on the surface of or within the cell. This molecular structure is called a receptor. The combination of the drug and the receptor results in a molecular change in the receptor, such as an altered configuration or charge distribution, and thereby triggers a chain of eve...

7. Pharmacogenetics of Drug Receptors

Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment can develop so called adverse drug reactions (ADRs) as a consequence of the treatment (cause over 100 000 deaths per year in USA). Pharmacogenetics is the discipline, which takes the patient’s genetic information of drug transporters, drug metabolising enzymes and drug receptors into account leadin...